Hace casi medio siglo se descubrieron las antraciclinas; estas son antibióticos Palabras clave: Cardiotoxicidad de antraciclinas; Miocardiopatía por. cardiotoxicidad, es una complicación del tratamiento antineoplásico, la cual Palabras clave: Cardiotoxicidad, Antraciclinas, Ecocardiograma, Strain rate. PURPOSE: We determined the frequency of and risk factors for congestive heart failure following treatment for Wilms’ tumor that included doxorubicin.

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Potentiation of doxorubicin cardiotoxicity by iron loading in a rodent model.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

Multicenter randomized phase III trial of epirubicin plus paclitaxel vs epirubicin followed by paclitaxel in metastatic breast cancer patients: Symptoms and signs of an acute myocardial ischemia caused by chemotherapy with Paclitaxel Taxol in a patient with metastatic ovarian carcinoma.

Las antraciclinas son antibioticos citotoxicos que se utilizan en el tratamiento de diferentes tipos de cancer. Tandara L, Salamunic I. Oxidative stress is the most widely studied mechanism and it involves a highly complex pathophysiology, which is a matter of permanent debate. G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: The Childhood Cancer Survivor Study. Statin Use and the Risk of Liver Cancer: Disruption of energetic mechanisms The integrity of mitochondrial function is of cornerstone importance in the physiology of myocardial cells, as ATP production is highly dependent on this organelle almost all of the ATP used by cardiac cells is produced by the electron transport chain.


J Natl Med Assoc. Anthraycline cardiotoxicity from bench to bedside.

The clinical impact of a cardiologic follow-up in breast cancer survivors: Perioperative hypothermia does not enhance the risk of cancer dissemination. In their same study, doxorubicin induced cardiac transcription factor GATA4 GATA Binding Protein 4, thought to regulate genes involved in myocardial differentiation and function, including CARP depletion, suggesting a co-dependent role for both proteins in maintaining sarcomere structure. J Natl Cancer Inst. Anticancer drugs antraxiclinas cardiotoxicity: Early goal-directed therapy after major surgery reduces complications and duration of hospital stay.

Expert Rev Anticancer Ther.

Brana I, Tabernero J. Left ventricular ejection fraction and cardiotoxicity: Perioperative management of patients receiving oral anticoagulants: Recent advances in breast cancer radiotherapy: Clinical heart failure in a cohort of children treated with anthracyclines: Cobos CamposA.

Anthracyclines are cytostatic antibiotics discovered almost half a century ago exerting their action through antrzciclinas of topoisomerase II. Cardiotoxicity of anticancer drugs: Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.

Free radicals in biology and medicine. Cardiovascular toxicity following sunitinib therapy in metastatic renal cell carcinoma: Interactions between doxorubicin and the human iron regulatory system. Green 61 Estimated H-index: CA Cancer J Clin. Exercise interventions during cancer treatment: J Heart Lung Transplant.

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma.

Halliwell B, Gutteridge J. Colorectal cancer and atrial fibrillation: We will not review in the present work the rare, but existent, acute presentation of anthracycline toxicity or the involvement of the pericardium.


Prolonged monitoring of troponin T for the cardiootoxicidad of anthracycline cardiotoxicity in adults with hematological malignancies. Iron metabolism Iron has a major role in cell metabolism and is under control by several regulatory systems. J Am Coll Cardiol.


Predicting difficult intubation in apparently normal patients: Bradycardia induced by irinotecan: Protective effect of carvedilol on daunorubicin-induced cardiotoxicity and nephrotoxicity in rats. Na Tabela 5sugerimos monitoramento por eletrocardiograma ECG. A prospective randomized trial of adjuvant chemotherapy with bolus versus continuous infusion of doxorubicin in patients with high-grade extremity soft tissue sarcoma and an analysis of prognostic factors.

Striking increase of natriuresis by low-dose spironolactone in congestive heart failure only in combination with ACE inhibition: Predicting and preventing cardiotoxicity in the era of breast cancer targeted therapies. Ref 9 Source Add To Collection.

Atrial fibrillation after thoracic surgery for lung cancer: Eur J Med Res.

Other mechanisms involved include the formation of DNA adducts by semiquinone or the generation of superoxide anions by anthracycline metabolism, with subsequent cellular damage by degradation of the sarcomere, mitochondrial dysfunction and DNA damage.

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